Phase 1 Sepsis trials: Trial Insights

Filters: Condition: Sepsis Phase: Phase 1 Clear all

65 trials match Source: ClinicalTrials.gov registrations

Top lead sponsors
Category	Trials
Phillip Brian Smith	4
Bristol-Myers Squibb	3
Mayo Clinic	3
Bayer	2
Biomedizinische Forschungs gmbH	2
Children's Hospital of Philadelphia	2
GlaxoSmithKline	2
Hartford Hospital	2
Joseph L. Kuti, PharmD	2
Sirtris, a GSK Company	2

Top conditions
Category	Trials
Sepsis	65
Shock, Septic	15
Critical Illness	5
Inflammation	4
Premature Birth	4
Respiratory Distress Syndrome	3
Acute Lung Injury	2
Disseminated Intravascular Coagulation	2
Hemostatic Disorders	2
Lung Diseases	2

Trials

Showing 26 to 50 of 65. Each trial links to its page on Pharma Observatory.

Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis: A Pilot Feasibility Study NCT03340805Phase 1CompletedChildren's Hospital of PhiladelphiaStarted 2018
Midodrine Hydrochloride in Early Sepsis NCT03129542Phase 1CompletedMayo ClinicStarted 2017
Study of Multiple-dose Kukoamine B Mesilate in Sepsis Patients NCT03237728Phase 1CompletedTianjin Chasesun Pharmaceutical Co., LTDStarted 2017
A Study of Nivolumab Safety and Pharmacokinetics in Patients With Severe Sepsis or Septic Shock. NCT02960854Phase 1CompletedBristol-Myers SquibbStarted 2016
Pharmacokinetics, Safety, Tolerability and Pharmacodynamics of BMS-986189 in Healthy Subjects NCT02739373Phase 1CompletedBristol-Myers SquibbStarted 2016
Safety, Pharmacokinetics and Pharmacodynamics of BMS-936559 in Severe Sepsis NCT02576457Phase 1TerminatedBristol-Myers SquibbStarted 2015
Amendment of rTSST-1 Variant Vaccine Phase 1 Clinical Trial NCT02971670Phase 1CompletedBiomedizinische Forschungs gmbHStarted 2015
Randomized, Parallel Group, Placebo Control, Unicentric, Interventional Study to Assess the Effect of Expanded Human Allogeneic Adipose-derived Mesenchymal Adult Stem Cells on the Human Response to Lipopolysaccharyde in Human Volunteers NCT02328612Phase 1CompletedTigenix S.A.U.Started 2014
rTSST-1 Variant Vaccine Phase 1 First-in-man Trail NCT02340338Phase 1CompletedBiomedizinische Forschungs gmbHStarted 2014
Cystatin-C C-guided Vancomycin Dosing in Critically Ill Patients: A Quality Improvement Project NCT02945241Phase 1CompletedMayo ClinicStarted 2014
Impact of Dopamine Infusion on Insulin Secretion in Healthy Subjects NCT02053935Phase 1CompletedAlbert Einstein College of MedicineStarted 2013
Effects of Transvenous Vagus Nerve Stimulation on Immune Response: a Pilot Study NCT01944228Phase 1CompletedMedtronic Cardiac Rhythm and Heart FailureStarted 2013
An Open Label Study to Describe the Pharmacokinetics of Cefazolin in Preterm Neonates NCT00850122Phase 1CompletedPhillip Brian SmithStarted 2013
Melatonin in Healthy Volunteers NCT01724424Phase 1CompletedUniversity of AberdeenStarted 2012
Detoxified J5 Core Glycolipid/ Group B Meningococcal Outer Membrane Protein Vaccine for Gram-negative Bacterial Sepsis Administered With and Without Synthetic CPG Oligodeoxynucleotide 7909 Adjuvant NCT01164514Phase 1TerminatedNational Institute of Allergy and Infectious Diseases (NIAID)Started 2011
A Study to Describe the Pharmacokinetics of Acyclovir in Premature Infants (PTN_Acyclo) NCT00942084Phase 1CompletedPhillip Brian SmithStarted 2011
Effect of Multiple Dose Levels of SRT2379 on Endotoxin-Induced Inflammation NCT01416376Phase 1CompletedSirtris, a GSK CompanyStarted 2011
The Effects of Sedative on the Fluid Responsiveness in Critically Ill Patients NCT01447875Phase 1CompletedSoutheast University, ChinaStarted 2011
Clinical Assessment of Safety and Tolerability of the New Monoclonal Humanized Antibody CaCP29 NCT01319903Phase 1CompletedInflaRx GmbHStarted 2011
Effect of SRT2379 on Endotoxin-Induced Inflammation NCT01262911Phase 1CompletedSirtris, a GSK CompanyStarted 2011
Metronidazole Pharmacokinetics (PK) in Premature Infants NCT01222585Phase 1CompletedMichael Cohen-WolkowiezStarted 2011
Zinc Therapy in Critical Illness NCT01162109Phase 1CompletedUniversity of VermontStarted 2010
AB103 Peptide Antagonist in Healthy Volunteers NCT01166984Phase 1CompletedAtox Bio LtdStarted 2010
L-Carnitine Administration in Early Sepsis NCT01193777Phase 1TerminatedWake Forest University Health SciencesStarted 2010
Pharmacokinetics and Safety of Ticarcillin-clavulanate in Infants NCT01229046Phase 1WithdrawnPhillip Brian SmithStarted 2010

A Study to Learn About How Safe BAY 3389934 is, Its Suitable Dose, and How it Affects the Participants With Sepsis Induced Coagulopathy NCT06854640Completion date change2027-01-17 to 2027-02-15October 18, 2026

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