Phase 3 trials in Italy: Trial Insights

Filters: Phase: Phase 3 Country / region: Italy Clear all

5,536 trials match Source: ClinicalTrials.gov registrations

Trials started per year
Category	Trials
2000	37
2001	57
2002	66
2003	95
2004	127
2005	139
2006	177
2007	200
2008	232
2009	218
2010	210
2011	227
2012	220
2013	223
2014	213
2015	244
2016	211
2017	249
2018	261
2019	264
2020	258
2021	307
2022	259
2023	251
2024	262
2025	262
2026	153

Top lead sponsors
Category	Trials
Hoffmann-La Roche	308
Novartis Pharmaceuticals	303
AstraZeneca	239
Pfizer	169
Sanofi	166
Eli Lilly and Company	164
Bristol-Myers Squibb	155
GlaxoSmithKline	150
Boehringer Ingelheim	119
Merck Sharp & Dohme LLC	115

Top conditions
Category	Trials
Carcinoma, Non-Small-Cell Lung	227
Breast Neoplasms	216
Diabetes Mellitus, Type 2	151
Neoplasms	129
Neoplasm Metastasis	111
Multiple Myeloma	90
Prostatic Neoplasms	81
Diabetes Mellitus	79
Colorectal Neoplasms	78
Pulmonary Disease, Chronic Obstructive	77

Trials

Showing 51 to 75 of 5,536. Each trial links to its page on Pharma Observatory.

A Study to Find Out How Nerandomilast is Tolerated, Handled by the Body, and if it Helps Children and Adolescents With Interstitial Lung Disease (FIBRONEER-chILD) NCT07366034Phase 3RecruitingBoehringer IngelheimStarted 2026
Clinical Evaluation of a Toothpaste for Dental Plaque Reduction and Prevention of Gum Problems NCT07842991Phase 3RecruitingColgate PalmoliveStarted 2026
An Open-label Study to Investigate the Efficacy and Safety of Dato-DXd + Rilvegostomig vs SoC in Adult Participants With High-risk MIUC NCT07720284Phase 3RecruitingAstraZenecaStarted 2026
A Phase 3 Study of Fenfluramine Hydrochloride in Rett Syndrome NCT07503444Phase 3RecruitingUCB BIOSCIENCES, Inc.Started 2026
PET Guided Dose Reduction for InvOlved Site Radiotherapy In Early sTage Unfavourable Hodgkin Lymphoma NCT07256158Phase 3RecruitingFondazione Italiana Linfomi - ETSStarted 2026
DAREON®-NEC-1: A Study in People With Advanced Extrapulmonary Neuroendocrine Cancer (epNEC) to Compare Obrixtamig Plus Carboplatin and Etoposide Treatment With Standard Chemotherapy NCT07544654Phase 3RecruitingBoehringer IngelheimStarted 2026
A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus NCT07662213Phase 3RecruitingAstraZenecaStarted 2026
Trial to Assess the Efficacy of EMPAgliflozin and Personalized Dietary Counseling for Kidney STONE Prevention NCT06653738Phase 3RecruitingInsel Gruppe AG, University Hospital BernStarted 2026
Pridopidine Phase 3 Study in Huntington's Disease NCT07609108Phase 3RecruitingPrileniaStarted 2026
A Master Protocol to Investigate Efficacy and Safety of Elecoglipron in Participants With Obesity or Overweight With or Without T2DM NCT07667803Phase 3RecruitingAstraZenecaStarted 2026
Optimising Adjuvant Chemotherapy Prescription in Young Patients With Hormone-dependent Breast Cancer Using Genomic Tests NCT07106632Phase 3RecruitingUNICANCERStarted 2026
Study of AZD0120 in Newly Diagnosed Multiple Myeloma Ineligible for ASCT NCT07764978Phase 3RecruitingAstraZenecaStarted 2026
Cevostamab in Combination With Pomalidomide and Dexamethasone Versus Standard of Care in Participants With Previously Treated Multiple Myeloma NCT07555938Phase 3RecruitingHoffmann-La RocheStarted 2026
A Clinical Trial of Calderasib (MK-1084) and Durvalumab in People With Non-Small Cell Lung Cancer (MK-1084-015/KANDLELIT-015) NCT07554339Phase 3RecruitingMerck Sharp & Dohme LLCStarted 2026
A Phase IIIb Study to Evaluate Camizestrant Plus Ribociclib in ER-positive, HER2-negative Advanced Breast Cancer NCT07647328Phase 3RecruitingAstraZenecaStarted 2026
IGNITE: Study of Tirabrutinib vs Rituximab/Temozolomide for Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL) NCT07104032Phase 3RecruitingOno Pharmaceutical Co., Ltd.Started 2026
A Study to Evaluate How Pozelimab + Cemdisiran Combination Therapy Works in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Whose Current Treatment is Not Working Efficiently NCT07154745Phase 3RecruitingRegeneron PharmaceuticalsStarted 2026
A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity NCT07595549Phase 3RecruitingPfizerStarted 2026
Pivotal Open-label Phase 3 Clinical Study of QTX-2101 in Adult Patients With Acute Promyelocytic Leukemia NCT07504458Phase 3RecruitingQuetzal TherapeuticsStarted 2026
Phase III Randomized International Open Label Clinical Trial of Treatment Intensification With Docetaxel Plus Apalutamide in Patients With Metastatic Hormone-sensitive Prostate Cancer Who Did Not Achieve a Deep PSA Response After Initial Treatment With Apalutamide: REINFORCE Trial. NCT07333066Phase 3RecruitingAlianza multidisciplinar para la investigación de los tumores genitourinarios -GUARDStarted 2026
Open-Label Extension Study of BBP-418 (Ribitol) for LGMD2I/R9 NCT07678775Phase 3Active, not recruitingML Bio Solutions, Inc.Started 2026
A Study to Evaluate the Efficacy of NIO752 in Participants With Progressive Supranuclear Palsy NCT07498426Phase 3RecruitingNovartis PharmaceuticalsStarted 2026
An Efficacy and Safety Study of Cenegermin Ophthalmic Solution Compared With Vehicle in the Treatment of PCED NCT07519902Phase 3RecruitingDompé Farmaceutici S.p.AStarted 2026
A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction NCT07192952Phase 3RecruitingBayerStarted 2026
Confirmatory Study of Govorestat in CMT-SORD NCT07191912Phase 3WithdrawnApplied Therapeutics, Inc.Started 2026

5,436 more trials match. See them on Pharma Observatory

Torvutatug Samrotecan With or Without Bevacizumab as Maintenance Treatment of Platinum-sensitive Relapsed Epithelial Ovarian Cancer NCT07816666Completion date change2031-10-27 to 2031-10-30October 18, 2026
Crohn's Disease: Efficacy, Safety, and Pharmacokinetics of Upadacitinib in Pediatric Subjects With Moderately to Severely Active Crohn's Disease NCT06332534Completion date change2034-12-31 to 2031-01-31October 18, 2026
A Study of Upadacitinib in Adult Participants With Moderate-to-Severe Atopic Dermatitis and Inadequate Response to Dupilumab NCT06389136Completion date change2027-03-31 to 2027-05-31October 18, 2026
A Study to Assess Adverse Events and Change in Disease Activity Comparing Oral Upadacitinib to Subcutaneous Dupilumab in Children From 2 to Less Than 12 Years of Age With Moderate to Severe Atopic Dermatitis NCT06461897Completion date change2030-07-31 to 2029-11-30October 18, 2026
An Extension Study Evaluating 6-week Treatment Cycles of Rozanolixizumab in Pediatric Study Participants With Generalized Myasthenia Gravis NCT06540144Completion date change2027-08-17 to 2027-10-05October 18, 2026
Randomised Clinical Trial to Investigate Efficacy and Safety of Benralizumab 30 mg SC as an add-on Therapy in Uncontrolled Eosinophilic Asthma Patients Treated With Medium-dose ICS-LABA Compared to Conventional Escalation to High-dose ICS-LABA Treatment NCT06750289Completion date change2028-11-03 to 2026-09-21October 18, 2026
Colchicine For The Prevention Of Perioperative Atrial Fibrillation In Patients Undergoing Thoracic Surgery (COP-AF) NCT03310125Completion date change2023-07-26 to 2023-06-23October 18, 2026
A Study of Ripretinib vs Sunitinib in Advanced GIST Patients After Treatment With Imatinib NCT03673501Completion date change2026-12-31 to 2027-12-31October 18, 2026
A Study With Eptinezumab in Adolescents (12-17 Years) With Chronic Migraine NCT04965675Completion date change2026-10-31 to 2027-03-26October 18, 2026
A Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Satralizumab in Participants With Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease NCT05271409Enrollment change132 to 139October 18, 2026

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