Clinical trials
Phase 2 Major Depressive Disorder trials in the United States
Search ClinicalTrials.gov registrations by keyword, then narrow by condition, phase, status, country and start year.
261 trials match Source: ClinicalTrials.gov registrations
Trials started per year
By phase, 2000 to 2026.
| Category | Trials |
|---|---|
| 2001 | 4 |
| 2002 | 2 |
| 2003 | 7 |
| 2004 | 8 |
| 2005 | 4 |
| 2006 | 5 |
| 2007 | 7 |
| 2008 | 16 |
| 2009 | 12 |
| 2010 | 11 |
| 2011 | 13 |
| 2012 | 8 |
| 2013 | 10 |
| 2014 | 13 |
| 2015 | 9 |
| 2016 | 7 |
| 2017 | 9 |
| 2018 | 8 |
| 2019 | 4 |
| 2020 | 11 |
| 2021 | 14 |
| 2022 | 10 |
| 2023 | 13 |
| 2024 | 19 |
| 2025 | 18 |
| 2026 | 15 |
Status
Trials by registry status. Select a bar to filter.
| Category | Trials |
|---|---|
| Completed | 174 |
| Recruiting | 35 |
| Terminated | 28 |
| Withdrawn | 7 |
| Active, not recruiting | 6 |
| Not yet recruiting | 4 |
| Unknown status | 4 |
| Suspended | 2 |
| Enrolling by invitation | 1 |
Top lead sponsors
A sponsor with a page on Pharma Observatory links to it.
| Category | Trials |
|---|---|
| National Institute of Mental Health (NIMH) | 15 |
| Massachusetts General Hospital | 13 |
| Janssen Research & Development, LLC | 11 |
| Alto Neuroscience | 7 |
| GlaxoSmithKline | 7 |
| Icahn School of Medicine at Mount Sinai | 7 |
| Otsuka Pharmaceutical Development & Commercialization, Inc. | 6 |
| University of Pittsburgh | 6 |
| AstraZeneca | 5 |
| Brigham and Women's Hospital | 5 |
Top conditions
MeSH conditions the trials were registered with, not their broader categories. A condition with a page on Pharma Observatory links to it.
| Category | Trials |
|---|---|
| Major Depressive Disorder | 261 |
| Depressive Disorder, Treatment-Resistant | 30 |
| Depressive Disorder | 29 |
| Mood Disorders | 24 |
| Mental Disorders | 13 |
| Anxiety Disorders | 12 |
| Bipolar Disorder | 9 |
| Inflammation | 8 |
| Anhedonia | 7 |
| Alcoholism | 6 |
Trials
Showing 1 to 25 of 261. Each trial links to its page on Pharma Observatory.
161 more trials match. See them on Pharma Observatory
Recently changed trials
Changes observed in the last 7 days, newest first, site-count changes left out. Source: ClinicalTrials.gov.
No changes to these trials in the last 7 days.
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